A Clinically Intriguing Case of One Sided Axillary Lipoma and Other Sided Axillary Hidrocystadenoma in the Same Patient-Case Report

CASE REPORT Open Access Volume 4 | Issue 4 ScholArena | www.scholarena.com SAJ Case Reports


Introduction
Hidrocystadenomas are rare cystic lesions of sweat glands, usually in the head and neck regions commonly seen on the eyelids [1].They are not solid tumors (a similar sounding lesion called hidroadenoma is a benign solid tumor).There are three types of "sweat" glands: True sweat glands or eccrine glands, sebaceous glands which have an oily secretion around hair follicles and apocrine glands which have more oily product than eccrine glands and are found on the face, armpit and groin.Hidrocysadenomas usually arise from apocrine glands.They are also called Cysts of Moll or sudoriferous cysts.Lipomas are another group of benign lesions which are commonly subcutaneous or superficial and composed of mature adipose tissue separated by thin septae.These tumors can be admixed with areas of spindle cells or vascular proliferation and are typed accordingly.However, when occurring they can be single or multiple just like hidrocystadenomas, however, co-occurrence of two benign lesions totally indistinct occurring simultaneously is intriguing.Here we report a case of eccrine hidrocystadenoma in the axillary region with a coexisting lipoma on the other side of the axilla in a 30yr old female.
Volume 4 | Issue 4 ScholArena | www.scholarena.comwhite.Representative sections were taken and stained with HnE.Microscopically the cystic tissue shows tissue lined by squamous epithelium.The underlying dermis shows fibrocollagenous and fibrofatty tissue (Figure 1).Dermis also shows cystic lesions which are lined with two layers of small, cuboidal epithelial cells.In some areas, only a single layer of flattened epithelial cells seen and their flattened nuclei extending parallel to the wall seen.The section also shows unremarkable skin appendages.The sections from another side of axillary swelling show lobules of mature adipocytes with intervening fine fibrous septa containing thin-walled blood vessels.No special stains were performed due to straightforward diagnosis.A diagnosis of eccrine hydrocystadenoma was made for the swelling in the one side axilla while lipoma was diagnosed for the swelling on the other side (Figure 2).Patient consent was taken before publication.
Hidrocystadenomas most commonly found in the head and neck region, whether eccrine or apocrine are benign lesions of the sweat glands.They occur predominantly in the face and malar region.They occur more commonly in females and are usually small 1-6mm in diameter, tense thin-walled cysts, occurring as single or multiple lesions [1].Apocrine hidrocystadenomas arise from the proliferation of apocrine glands and are usually solitary, measuring 3 to 15 mm in diameter [1].Most common site of occurrence of these lesions is the head and neck region and around the lid margin near the inner canthus of the eye [2].Eccrine lesions are more likely than apocrine lesions to occur at periorbital regions.The general distribution of lesions tends to occur in similar locations on the body for both the hidrocystadenomas [1].Eccrine hidrocystadenomas are rare, benign, cystic lesions occurring predominantly on the face, and associated with a chronic course and seasonal variation.Lipomas are another group of benign lesions which are commonly subcutaneous or superficial and composed of mature adipose tissue separated by thin septae.These tumors can be admixed with areas of spindle cells or vascular proliferation and are typed accordingly.However, when occurring they can be single or multiple just like hidrocystadenomas however co-occurrence of two benign lesions totally indistinct occurring simultaneously is intriguing.Differentiation from apocrine hidrocystadenomas poses a problem both clinically and histologically.Apocrine hidrocystadenomas are often larger, darker blue in color and less likely to be periorbital [3].On histological examination, eccrine hidrocystadenomas which are lined by ductal cells differ from apocrine hidrocystadenomas by the absence of decapitation secretion, PAS-positive granules and myoepithelial cells.Eccrine hidrocystadenomas are generally unilocular whereas apocrine hidrocystadenomas are usually multilocular [3].A controversy exists whether eccrine hidrocystadenomas are rare or not [4,5].

Discussion
These are rare and usually asymptomatic and are often of interest to physicians of different specialties.The close resemblance of these lesions to serious skin disorders such as basal cell carcinomas necessitates an understanding of the histology of each type of hidrocystadenoma for the purposes of differential diagnosis.In this case we came across an interesting case of eccrine hidrocystadenoma in a rare location like the axilla co-occurring with another isolated benign lesion, a large lipoma, on the other sided axilla, a deviation from its normal pattern.

Conclusion
Clinically, it is important to differentiate eccrine hidrocystadenomas from another cyst like lesions like sebaceous and epidermal inclusion cysts, mucin cysts, hemangiomas and lymphangomas and pigmented cystic type of basal cell carcinomas [6,7].A biopsy of the lesion is necessary to exclude these diagnosis.Hidrocysadenomas of the ear is very rare however they occur and pose a problem for cosmetic as well as functional activity [8].They are cosmetically undesirable as a result of their predominant facial location.The treatment of multiple eccrine hidrocystomas remains a challenge.The effect of atropine is variable and aggressive surgical excision may lead to scarring [7].